Exploring the Importance of rRNA Genes in Protein Synthesis: Insights on the Highly Repeated Nucleolus Organizer Region (NOR) on Human Chromosomes

In humans, rRNAs are coded for by a. separate genes. b. single copy genes. c. multiple copies of three genes. d. multiple copies of RNA genes. e. a transposon.


In humans, rRNAs are coded for by multiple copies of RNA genes. These RNA genes are located in a highly repeated region of the genome known as the nucleolus organizer region (NOR), found on the short arm of chromosomes 13, 14, 15, 21, and 22. The NOR contains tandemly repeated units of DNA that encode the primary RNA transcript of the rRNA genes. The primary transcript is then processed into the mature 28S, 18S, and 5.8S rRNAs that are components of the ribosome. Overall, there are hundreds of copies of the rRNA genes in the human genome, and their high copy number reflects the importance of rRNA in protein synthesis.

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