This is the process of reducing solids into fine particles by rubbing them with a mortar and pestle. It is used to reduce the size of the particles and to blend powders.
trituration
The process described above is called “trituration”. Trituration is the act of grinding, reducing or comminuting solids into fine particles by rubbing them against a hard, rough surface such as a mortar and pestle. This process is commonly used in the pharmaceutical industry to reduce the particle size of active drug ingredients and to blend different powders prior to their use in the formulation of tablets and capsules.
Trituration is an important step in the preparation of many pharmaceutical products, especially when the drug substance is not readily soluble in water or other solvents. By reducing the particle size of the drug substance, trituration helps to increase its surface area, which in turn enhances its solubility and bioavailability.
To carry out trituration, a small amount of the solid material is placed in a mortar and then ground with a pestle until the desired particle size is achieved. It is important to use a mortar and pestle that is appropriate for the volume and consistency of the materials being ground. Additionally, care should be taken to ensure that the pestle is kept clean and dry to avoid contamination of the sample.
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