Virus Splitting: Balancing Safety and Immunogenicity in Inactivated Vaccine Development

Virus splitting ___________ vaccine safety but _____________ immunogenicity.

increases, reducses

Virus splitting is a process used in the development of some inactivated vaccines to increase their safety. This process involves reducing the infectivity of a virus by breaking it apart or “splitting” it into its individual components. This often involves treating the virus with chemicals or exposing it to physical conditions that cause it to break apart, which makes it unable to cause disease.

While virus splitting can increase vaccine safety by reducing the risk of side effects or infections caused by the vaccine, it also has the potential to decrease the immunogenicity of the vaccine. Immunogenicity refers to the ability of a vaccine to provoke an immune response in the body, which is essential in providing protection against the disease.

When the virus is split, certain components of the virus may be removed or damaged, which may reduce the ability of the vaccine to stimulate a strong immune response. To address this, vaccine manufacturers may add substances called adjuvants to the vaccine to help improve its immunogenicity, or they may use alternative vaccine technologies, such as live attenuated vaccines, which can better stimulate the immune system.

Overall, virus splitting can provide an important safety advantage in vaccine design but must be balanced with maintaining sufficient immunogenicity to ensure that the vaccine is effective in protecting against the targeted disease.

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