Retroviruses: The Significance and Challenges of Provirus Integration in Host Genomes

In retroviruses, the integrated phage genome is known as what?

provirus

It is important to note that retroviruses do not contain phage genomes as they are a type of virus that contain RNA genome and use reverse transcriptase to convert their RNA genome into DNA, which is then integrated into the host’s genome.

The integrated viral DNA genome in the host cell is known as a provirus. The provirus is a permanent part of the host’s genome and is replicated along with the host cell DNA. It can remain dormant or become activated and start producing new virus particles. This ability of the provirus to remain hidden or activated is one of the key reasons that retroviruses are difficult to treat and can cause long-term infections.

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