What was the first approved recombinant vaccine?
Hepatitis B in 1986 produced in S. cerevisiae
The first approved recombinant vaccine was the hepatitis B vaccine, which was developed in the 1980s using recombinant DNA technology. This vaccine is made by inserting the gene for a hepatitis B surface antigen into yeast cells, which then produce large amounts of the protein. The hepatitis B surface antigen is a protein that is found on the surface of the virus and is used by the immune system to identify and destroy the virus. By presenting this antigen to the immune system, the vaccine stimulates the production of antibodies that can protect against infection with the hepatitis B virus. The recombinant hepatitis B vaccine has been highly effective in preventing hepatitis B infection and is now a routine part of the childhood vaccination schedule in many countries around the world.
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