Optimizing Clinical Trials: The Benefits and Limitations of a Planned Crossover Design

In a randomized trial, a planned crossover design:a. Eliminates the problem of a possible order effectb. Must take into account the problem of possible residual effects of the first therapyc. Requires stratified randomizationd. Eliminates the need for monitoring compliance and noncompliancee. Enhances the generalizability of the results of the study

B – Must take into account the problem of possible residual effects of the first therapy

a. Eliminates the problem of a possible order effect – True. A planned crossover design involves switching the groups during the trial to eliminate the potential bias of order effects. In this design, each participant receives both treatments but in a different order to avoid the order effect bias.

b. Must take into account the problem of possible residual effects of the first therapy – True. A planned crossover design can be influenced by residual effects of previous treatments on future treatments. Therefore, researchers should take the residual effects of the first therapy into account when analyzing results.

c. Requires stratified randomization – False. Stratified randomization is not required for a planned crossover design. Instead, simple randomization can be used to assign participants to a sequence of treatments.

d. Eliminates the need for monitoring compliance and noncompliance – False. The planned crossover design does not eliminate the need for monitoring compliance and noncompliance. Researchers must keep track of the participants’ compliance and noncompliance to each of the interventions to interpret the results accurately.

e. Enhances the generalizability of the results of the study – False. A planned crossover design may not enhance the generalizability of the results of the study. The results can be limited to the specifics of the study, reducing their generalizability to the wider population.

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