How does adding a beta-lactamase inhibitor agent help achieve a therapeutic effect when prescribed for otitis media? A. It extends the spectrum of antibacterial activity of penicillin. B. It extends the spectrum of the beta-lactamase inhibitor. C. It decreases the side effects of high-dose penicillin. D. It increases the absorption of the penicillin.
A
The correct answer is A.
Beta-lactam antibiotics, such as penicillins and cephalosporins, are commonly prescribed for the treatment of bacterial infections, including otitis media. However, some bacterial strains can produce an enzyme called beta-lactamase, which can break down the beta-lactam ring present in these antibiotics and render them ineffective.
Beta-lactamase inhibitors, such as clavulanate, sulbactam, and tazobactam, act by binding to and inhibiting the beta-lactamase enzyme, thus preventing it from degrading the antibiotic. This allows the antibiotic to remain active and effectively kill the bacteria causing the infection.
In the case of otitis media, the addition of a beta-lactamase inhibitor to a penicillin antibiotic can extend the spectrum of antibacterial activity, as it can effectively treat beta-lactamase-producing strains of bacteria. This can lead to a better therapeutic effect and higher rates of treatment success.
Therefore, option A is the correct answer. Options B, C, and D are not true statements regarding the mechanism of action of beta-lactamase inhibitors in otitis media.
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