Understanding the Roles and Effects of Hematopoietic Growth Factors on Blood Cell Development

Which of the following does not accurately describe hematopoietic growth factors?A. Bind to target cell receptors to expressactivityB. Action of majority is lineage restrictedC. May promote or suppress cell deathD. Can stimulate or inhibit cellproliferation

The correct answer is B

The correct answer is B. Action of the majority is lineage restricted.

Hematopoietic growth factors are substances that regulate the production and development of blood cells in the bone marrow. They play a crucial role in maintaining a balanced and functional blood cell population. Hematopoietic growth factors can be classified into various categories based on their specific actions and effects on different blood cell lineages.

A. Hematopoietic growth factors bind to target cell receptors to express activity. This is an accurate description because these growth factors exert their effects by binding to specific receptors on the target cells, initiating a series of molecular events that lead to changes in gene expression and cellular activity.

B. The action of the majority of hematopoietic growth factors is not lineage restricted. This statement is not accurate. In fact, hematopoietic growth factors can have both lineage-restricted and more broadly acting effects. Some growth factors, such as erythropoietin, specifically promote the production and maturation of red blood cells, whereas others, like granulocyte colony-stimulating factor (G-CSF), stimulate the production of white blood cells. However, there are also growth factors, such as stem cell factor (SCF), that have a more general role in promoting the growth and development of multiple blood cell lineages.

C. Hematopoietic growth factors may promote or suppress cell death. This statement is accurate. Depending on the specific growth factor and the cellular context, hematopoietic growth factors can either promote cell survival by preventing programmed cell death (apoptosis) or induce apoptosis in certain situations. For example, some growth factors, such as interleukin-3 (IL-3), play a critical role in preventing apoptosis and promoting the survival of hematopoietic stem cells and progenitor cells.

D. Hematopoietic growth factors can stimulate or inhibit cell proliferation. This statement is accurate. The primary function of hematopoietic growth factors is to regulate the proliferation and differentiation of blood cells. Some growth factors, like G-CSF or thrombopoietin, directly stimulate the division of specific blood cell precursors, leading to increased production of mature blood cells. On the other hand, other growth factors, such as transforming growth factor-beta (TGF-beta), can inhibit cell proliferation and promote cell differentiation.

In conclusion, the statement that does not accurately describe hematopoietic growth factors is B. The action of the majority is lineage restricted.

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