Pathology | Senioritis

Mohamed Abbas
July 4, 2023
Pathology

Exploring the Role of CCND1 Overexpression in Mantle Cell Lymphoma: A Molecular Perspective for Targeted Therapies

MCLt(11:14)FISH, PCR, RTPCRMutations increase expression of CCND1 forcing cells from G1 to S phase. Affects B cells and develops in the mantle zone in the lymph node....

Mohamed Abbas
July 4, 2023
Pathology

Unlocking the Potential: The Significance of the c-myc Gene in Gene Regulation and Cancer Development

BLt(8:14)FISH, CISHc-myc gene codes for transcription factor that controls transcription of other genes The c-myc gene is an important gene that codes for a transcription factor The...

Mohamed Abbas
July 4, 2023
Pathology

A Step-by-Step Guide to Designing Primers for Translocation-Specific PCR: Understanding, Gene Sequences, Breakpoints, Designing Criteria, Validation

RMS/ARMScancer/solid tumort(2:13) or t(1:13)RTPCR, FISHPCR primers designed to yield product only if translocation has occurred To design primers for a translocation-specific PCR (Polymerase Chain Reaction), such as...

Mohamed Abbas
July 4, 2023
Pathology

Unraveling the Genetic Landscape of Breast Cancer: Insights from Chromosome 17 and Molecular Techniques.

Breast cancerChromosome 17IHC (Immunohistochemistry), FISH, CISHTyrosine phosphatase (adds phosphates to tyrosines)25-30% of all breast cancersHerceptin is the main drug since it’s a tyrosine kinase inhibitor Breast cancer...

Mohamed Abbas
July 4, 2023
Pathology

Understanding Freckles: Causes, Characteristics, and How to Protect Your Skin

Freckles (Ephelis) Freckles, also known as ephelis, are small spots that appear on the skin, particularly on the face, arms, and shoulders Freckles, also known as ephelis,...

Mohamed Abbas
July 4, 2023
Pathology

Understanding Café au Lait Spots: Causes, Symptoms, and Genetic Associations

Cafe au lait spots melanosomes Café au lait spots are light brown to dark brown patches on the skin that can vary in size and shape Café...

Mohamed Abbas
July 4, 2023
Pathology

Understanding and Managing Lentigo: Causes, Prevention, and Treatment

Lentigo Lentigo is a common skin condition characterized by small, flat, and dark spots on the skin Lentigo is a common skin condition characterized by small, flat,...

Mohamed Abbas
July 4, 2023
Pathology

Understanding Melanocytic Nevi: Types, Characteristics, and Potential Risks to Skin Health

Melanocytic nevus A melanocytic nevus, commonly known as a mole, is a benign growth on the skin A melanocytic nevus, commonly known as a mole, is a...