What does the autohemolysis test measure?
Structural and metabolic integrity of RBC membrane
The autohemolysis test is a laboratory test that measures the rate at which red blood cells (erythrocytes) break down in an individual’s own blood sample. It is used to assess the health of the red blood cells and to diagnose certain conditions such as paroxysmal nocturnal hemoglobinuria (PNH).
In the test, a small sample of the individual’s blood is collected and then incubated at a specific temperature and for a specific period of time. After incubation, the degree of hemolysis (breakdown of red blood cells) is measured by the presence of free hemoglobin in the plasma. The rate of hemolysis is expressed as a percentage of the total red blood cells present.
The autohemolysis test can be used to monitor the progression of PNH, a rare blood disorder that causes hemolysis and can result in anemia, blood clots, and other complications. The test can also be used to diagnose other conditions that cause abnormal hemolysis, such as hereditary spherocytosis, sickle cell disease, and some types of hemolytic anemia.
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