Consider the table below where a child and a possible father (PF) share the listed paternity indices for each locus listed (LOC-A1, LOC-B2, LOC-C3, LOC-D4).Locus Tested PF Child Paternity IndexLOC-A1 3 2/3 2.18LOC-B2 7/5 5 0.798LOC-C3 15/17 9/17 5.21LOC-D4 12 12 1.37Based on the data presented in the table, what is the combined paternity index, CPI, from the loci tested: LOC-A1, LOC-B2, LOC-C3 and LOC-D4?12.429.55815.562.38
To calculate the combined paternity index (CPI), you need to multiply the individual paternity indices for each locus together
To calculate the combined paternity index (CPI), you need to multiply the individual paternity indices for each locus together.
The paternity index (PI) for each locus is the ratio of the probability of paternity to the probability of non-paternity. It is calculated by dividing the frequency of the observed genotype in the child by the frequency of the observed genotype in the population.
Let’s calculate the CPI for the given loci:
CPI = (PI for LOC-A1) x (PI for LOC-B2) x (PI for LOC-C3) x (PI for LOC-D4)
From the table, the paternity indices for each locus are as follows:
PI for LOC-A1 = 2.18
PI for LOC-B2 = 0.798
PI for LOC-C3 = 5.21
PI for LOC-D4 = 1.37
Now, let’s calculate the CPI:
CPI = 2.18 x 0.798 x 5.21 x 1.37 ≈ 15.56
Therefore, the combined paternity index (CPI) from the loci tested: LOC-A1, LOC-B2, LOC-C3, and LOC-D4 is approximately 15.56.
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