Science | Senioritis

Mohamed Abbas
July 4, 2023
Medicine

Understanding the Role of Systemic Circulation in Drug Absorption through the Skin

The systemic circulation- the drug does not have to pass all the way through the dermis to access the blood (vessels are at the surface of the...

Mohamed Abbas
July 4, 2023
Medicine

Understanding Transdermal Drug Delivery: Penetration into Epidermis and Dermis and the Carry Over Effect

The drug builds up in the epidermis and dermis from the first patch, which continues to release the drug into the systemic circulation until the next patch...

Mohamed Abbas
July 4, 2023
Medicine

The Science Behind Transdermal Patches: Controlled Drug Delivery through Intact Skin

A product that is placed onto intact skin to deliver the drug to the systemic circulation – they are designed for prolonged drug release (up to 7...

Mohamed Abbas
July 4, 2023
Medicine

Optimizing Drug Penetration through the Stratum Corneum: Factors and Mechanisms

1. drug penetration through the stratum corneum 2. drug release from the patch Drug release from transdermal patches is controlled by diffusion mechanisms, matrix design, membrane properties,...

Mohamed Abbas
July 4, 2023
Medicine

Understanding the Impact of the Stratum Corneum on Drug Delivery: A Crucial Barrier for Controlled Release

The stratum corneum determines drug delivery rate- if it is broken, it could lead to toxic doses of the drug in systemic circulation The stratum corneum is...

Mohamed Abbas
July 4, 2023
Medicine

The Significance of Lipid-Water Partition Coefficient in the Distribution and Permeability of Lipophilic Drugs.

Lipophilic drugs – the most important variable determining Ptotal is the lipid-water partition coefficient Lipophilic drugs are drugs that have a high affinity for lipids or fat...

Mohamed Abbas
July 4, 2023
Medicine

Increasing the Size of Transdermal Patches for Enhanced Drug Delivery: Factors and Benefits

Its surface area- to increase dose delivered increase the size of the patch When it comes to drug delivery through transdermal patches, the surface area plays a...

Mohamed Abbas
July 4, 2023
Medicine

Optimzed the Advantages of Transdermal Drug Delivery Systems for Sustained Blood Levels and Improved Patient Adherence in Drug Administration

1. provides sustained blood levels with a single dose2. provides more consistent blood levels than multiple oral doses3. improve patient adherence compared to multiple oral doses4. avoid...