SOCl2/ pyridine
used to replace OH with Cl (No shifts)
The combination of SOCl2 and pyridine is commonly used in organic chemistry as a reagent for the conversion of alcohols to alkyl chlorides.
Pyridine is a basic solvent that can deprotonate compounds like alcohols and turn them into nucleophiles. SOCl2, on the other hand, is an electrophilic reagent that reacts with the nucleophilic alcohol to form a reactive intermediate, which is quickly attacked by chloride ions present in the reaction mixture. The final product of this reaction is an alkyl chloride.
The reaction of SOCl2 and pyridine is carried out in anhydrous conditions and under inert gas environment. This is because both pyridine and SOCl2 are highly reactive with water and air, leading to unwanted side reactions. The reaction is typically done at room temperature or slightly elevated temperature and takes about 1-2 hours to complete.
Overall, the combination of SOCl2 and pyridine is a powerful tool in organic chemistry for the preparation of alkyl chlorides from alcohols. However, caution should be exercised while handling these reagents due to their highly reactive nature.
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