Understanding Antifungal Medications: A Comprehensive Guide to Fluconazole and Amphotericin B

what are two antifungals?

fluconazole and nystatin

Antifungals are medications used to treat fungal infections in humans and animals. There are several types of antifungals, and two commonly used antifungals are:

1. Fluconazole: Fluconazole is a triazole antifungal medication commonly used to treat vaginal, oral and esophageal candidiasis, cryptococcal meningitis, and other fungal infections. It works by inhibiting the synthesis of ergosterol, a component of the fungal cell membrane, which leads to the disruption of fungal growth and replication.

2. Amphotericin B: Amphotericin B is a polyene antifungal medication used to treat systemic fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and cryptococcosis. It works by binding to the fungal cell membrane, causing it to become leaky and leading to the death of fungal cells. Because of its potential for severe side effects, such as kidney damage, it is usually reserved for severe or life-threatening fungal infections.

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