Understanding the Impact of the Stratum Corneum on Drug Delivery: A Crucial Barrier for Controlled Release

The stratum corneum determines drug delivery rate- if it is broken, it could lead to toxic doses of the drug in systemic circulation

The stratum corneum is the outermost layer of the skin, composed mainly of dead skin cells

The stratum corneum is the outermost layer of the skin, composed mainly of dead skin cells. It acts as a protective barrier, preventing substances from entering or leaving the body. When it comes to drug delivery, the intactness of the stratum corneum plays a crucial role.

The stratum corneum acts as a barrier to drug penetration. It is hydrophobic in nature, meaning that it repels water and lipophilic substances, such as certain drugs. This characteristic limits the permeability of the skin and prevents the rapid absorption of drugs, which is important in controlling their delivery rate.

If the stratum corneum is broken or damaged, it can compromise the integrity of the skin barrier and significantly increase drug penetration. This can lead to an increased drug delivery rate, resulting in potentially higher drug concentrations reaching the systemic circulation.

When a drug is applied topically, such as through a transdermal patch or cream, the intent is often to achieve a controlled release and absorption of the medication. The drug should be slowly released into the underlying layers of the skin and eventually reach the bloodstream in a controlled manner. However, if the stratum corneum is disrupted, the drug may bypass this layer and directly enter the underlying tissue. This can bypass the body’s natural defense mechanisms and lead to unintended toxicity or adverse effects.

Furthermore, the stratum corneum also serves as a barrier to microorganisms, preventing their entry into the body. If the barrier is compromised, there is an increased risk of skin infections and other complications.

Overall, the stratum corneum plays a vital role in determining the rate and extent of drug delivery through the skin. Breaking or damaging this layer can result in unintended consequences, such as toxic doses of the drug entering the systemic circulation. Therefore, it is essential to maintain the integrity of the stratum corneum when considering drug delivery strategies through the skin.

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