In acute renal failure, doses of which of the following antibiotics must be reduced? (Select all that apply.) A. nafcillin B. cefazolin C. meropenem D. aztreonam
B, C, D
In acute renal failure, doses of the following antibiotics must be reduced:
B. cefazolin
D. aztreonam
Cefazolin and aztreonam are eliminated primarily by the kidneys and their doses should be adjusted in case of renal impairment. Nafcillin and meropenem are mainly eliminated by the liver and do not require dose adjustments in patients with renal failure. However, the dosage of meropenem may need to be adjusted in patients with both renal and hepatic dysfunction.
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