Fructosamine interference
high levels of Vitamin C, hyperthyroidism
Fructosamine is a lab test used to determine a person’s average blood sugar level over a period of 2-3 weeks. It is used as an alternative to HbA1c test for assessing blood sugar control in people who have conditions that affect red blood cell lifespan or with hemoglobin variants.
However, fructosamine test results can be affected by certain factors, which are collectively referred to as interference. One of the main sources of interference in fructosamine testing is the presence of substances that bind with or react with fructosamine, leading to erroneous readings.
Some common substances that can interfere with fructosamine testing include hemoglobin variants, such as sickle cell anemia and thalassemia, medications such as ascorbic acid (vitamin C), ascorbic acid-containing supplements, bilirubin, and lipids.
To avoid interference, it is important to always disclose to your healthcare provider any medications and supplements you are taking, any medical conditions you have, and any dietary habits that may affect the fructosamine test results. Your healthcare provider may also request for other tests, such as HbA1c, as a complementary measure to verify blood sugar control.
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