Which of the following classes of cephalosporins have the best activity against gram-positive organisms? A. first-generation cephalosporins B. second-generation cephalosporins C. third-generation cephalosporins D. fourth-generation cephalosporins
A
The correct answer is C. third-generation cephalosporins.
Third-generation cephalosporins have the best activity against gram-positive organisms among the classes of cephalosporins. This is due to their extended spectrum of activity, which includes gram-positive cocci such as Streptococcus pneumoniae, Staphylococcus aureus, and coagulase-negative staphylococci.
First-generation cephalosporins have a narrow spectrum of activity that is limited mostly to gram-positive cocci and some gram-negative rods, while second-generation cephalosporins have a broader spectrum of activity that includes some gram-negative rods and anaerobic bacteria.
Fourth-generation cephalosporins have a broad-spectrum of activity against both gram-negative and gram-positive organisms; however, they are typically reserved for complicated infections and are not commonly used as first-line agents due to concerns regarding the development of antimicrobial resistance.
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