What cells do rotavirus invade and replicate? (Which immune system then destroys)
Mature enterocytes
Rotavirus primarily infects the cells that line the small intestine in humans and animals. These cells are known as enterocytes. Once the virus invades and replicates in these cells, it causes damage to the intestinal lining, leading to diarrhea, vomiting, and other gastrointestinal symptoms.
The immune system then works to destroy the infected cells and combat the virus. Both innate and adaptive immune responses are involved in the clearance of rotavirus from the body. The innate immune system, which includes natural killer cells, macrophages, and dendritic cells, responds quickly to the virus and helps to contain the infection.
The adaptive immune system, which includes B cells and T cells, responds more slowly but provides long-term protection against future infections. Once the adaptive immune system is activated, it generates antibodies that can neutralize the virus and memory B and T cells that can quickly respond to future infections.
In summary, rotavirus infects and replicates in cells lining the small intestine and is eventually cleared by both innate and adaptive immune responses.
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