Type I IFNs bind to the receptors on infected cells, which triggers the receptors to form ________ _____________ in the infected cell.
Type I IFNs (interferons) bind to the receptors on infected cells, which triggers the receptors to form signal complexes in the infected cell
Type I IFNs (interferons) bind to the receptors on infected cells, which triggers the receptors to form signal complexes in the infected cell.
When Type I IFNs bind to their specific receptors on the surface of infected cells, it initiates a signaling cascade within the cell. This signaling cascade leads to the activation and subsequent formation of signal complexes in the cytoplasm. These signal complexes are called Janus kinase-signal transducer and activator of transcription (JAK-STAT) complexes.
The JAK-STAT pathway plays a crucial role in the intracellular signaling induced by Type I IFNs. Once the IFNs bind to their receptors, the receptor-associated JAKs become activated and subsequently phosphorylate the STAT proteins. This phosphorylation facilitates the dimerization of STAT proteins, allowing them to translocate into the nucleus. Once in the nucleus, the activated STAT dimers bind to specific DNA sequences known as interferon-stimulated response elements (ISREs).
Binding of the activated STAT dimers to ISREs leads to the transcriptional upregulation of a variety of genes that are involved in the antiviral defense mechanisms. These include genes encoding antiviral proteins, immunomodulatory factors, and chemokines, among others. The upregulated gene products serve to establish an antiviral state in the infected cell and neighboring cells, promoting the clearance of the viral infection.
In summary, Type I IFNs binding to their receptors on infected cells triggers the formation of JAK-STAT signal complexes in the cytoplasm. Activation of the JAK-STAT pathway leads to the transcriptional upregulation of numerous antiviral genes, thereby enhancing the antiviral defense mechanisms within the infected cells.
More Answers:
The Role of Interferons in the Antiviral Response: Signaling Proteins that Activate Immune Defense Against VirusesThe Crucial Role of Type I Interferons in the Defense Against Viral Infections: Activation of PKR and Induction of Apoptosis
Role of JAK-STAT Pathway in Antiviral Defense: Activation by Type I IFNs in Infected Cells