GM-CSF (sargramostim)
Binds to a JAK/STAT receptor, multipotential hematopoietic growth factor that stimulates proliferation and differentiation of early and late granulocytic progenitor cells as well as erythroid and megakaryocyte progenitors.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring protein that stimulates the growth and development of bone marrow cells that ultimately give rise to white blood cells. In medical practice, GM-CSF is available for clinical use in the form of a drug called sargramostim.
Sargramostim is a recombinant form of human GM-CSF that is manufactured by genetic engineering using bacteria. It is used to stimulate the production of white blood cells in individuals with weakened immune systems, including cancer patients after bone marrow transplantation, individuals with HIV infection, and those undergoing chemotherapy treatment for cancer.
Sargramostim is given as an injection into the skin or muscle. The injection site may become red, sore, or swollen, but these side effects are usually mild and go away on their own. In some cases, sargramostim may cause more severe side effects, such as allergic reactions or infections. Therefore, patients receiving sargramostim should be carefully monitored for any adverse reactions.
Overall, sargramostim serves as an important tool in supporting the immune function of patients with weakened immune systems, ultimately improving their overall quality of life and reducing the risk of infections and other complications.
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