What complication should be suspected in a patient with HELLP syndrome with clinically significant bleeding and elevated prothrombin time (PT), partial thromboplastin time (PTT) and decreased fibrinogen?
disseminated intravascular coagulation (DIC)
In a patient with HELLP syndrome and clinically significant bleeding in addition to elevated PT, PTT and decreased fibrinogen, disseminated intravascular coagulation (DIC) should be suspected. DIC is a serious disorder that involves abnormal activation of the coagulation system, leading to the formation of blood clots in small blood vessels throughout the body, which can cause organ damage and bleeding.
In patients with HELLP syndrome, DIC can occur as a complication due to the release of tissue factor and other procoagulants from damaged liver tissue and placental cells. This can lead to the formation of blood clots in the body, which can consume clotting factors and other blood components, resulting in bleeding.
Therefore, it is important to closely monitor patients with HELLP syndrome who exhibit clinically significant bleeding and laboratory abnormalities including elevated PT, PTT and decreased fibrinogen. They should receive prompt and appropriate interventions, such as blood transfusions and treatment for DIC, to prevent further complications and improve outcomes.
More Answers:
Comprehensive Guide to Primary Amenorrhea Workup: History, Physical Examination, and Laboratory TestsEffective Treatments for Secondary Allergic Vulvitis: Topical Creams and Oral Antihistamines
How Endometrial Atrophy Affects Postmenopausal Women – Causes, Symptoms, and Importance of Regular Exams