Importance of the 3′ End in DNA and RNA Molecules

3′ end

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The 3′ end is one of the ends of a nucleic acid molecule such as DNA or RNA. The 3′ end specifically refers to the end of the molecule that has a free hydroxyl (-OH) group attached to the 3′ carbon of the sugar molecule in the nucleotide.

During DNA replication or transcription, new nucleotides are added to the 3′ end of the growing strand, which elongates the molecule. Additionally, certain enzymes and proteins that interact with DNA or RNA may recognize and bind to the 3′ end of the molecule to carry out specific functions.

The 3′ end is also important for the stability of the nucleic acid molecule. Chemical modifications or alterations to the 3′ end can affect the overall structure and function of the molecule. For example, truncation or damage to the 3′ end can prevent the molecule from forming proper base pairs or interacting with other molecules in the cell.

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