Understanding First-Generation Antipsychotics: Uses, Side Effects, and Risks

first-generation antipsychotics

drugs that treat the positive symptoms (ex: hallucinations, delusions) of schizophrenia -examples: thorazine, haldol, loxitane

First-generation antipsychotics, also known as typical antipsychotics, are a class of medications used to treat psychotic disorders such as schizophrenia. These drugs act primarily on the dopamine receptors in the brain to reduce symptoms of hallucinations, delusions, and disordered thinking.

Examples of first-generation antipsychotics include chlorpromazine, haloperidol, and perphenazine. These medications are commonly available in tablet or injection form.

Some common side effects of first-generation antipsychotics include drowsiness, dry mouth, weight gain, muscle stiffness, and tremors. Long-term use of these drugs may also increase the risk of tardive dyskinesia, a movement disorder characterized by uncontrollable muscle movements.

Overall, first-generation antipsychotics have been used for decades to successfully treat psychotic disorders. However, they are often associated with significant side effects and may not be effective for all patients. Newer antipsychotic medications, known as second-generation or atypical antipsychotics, have been developed that offer improved efficacy and fewer side effects for some patients.

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