The significance of Chloride in Human Physiology: Functions, Intake, and Imbalances Explained

Chloride

Cl⁻

Chloride is an anion (negatively charged ion) that is formed upon the removal of an electron from a chlorine atom. Chloride is important in several physiological processes, including the maintenance of a balance of fluids in the body, nerve and muscle function, and transport of substances in and out of cells.

Chloride is essential for the proper functioning of the human body and is obtained through the diet in the form of table salt (sodium chloride) and other foods. The recommended daily intake of chloride is about 2,300 mg per day.

Low levels of chloride in the body can lead to hypochloremia, which can cause symptoms such as nausea, vomiting, muscle cramps, and changes in blood pressure. High levels of chloride, known as hyperchloremia, can be caused by conditions such as dehydration or renal failure and can cause symptoms such as weakness, lethargy, and confusion.

In laboratory testing, chloride levels are measured as part of a basic metabolic panel (BMP) or a comprehensive metabolic panel (CMP), which are commonly ordered tests to evaluate overall health.

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