phosphoglycerate mutase
Rearranges 3-phosphoglycerate to 2-phosphoglycerate
Phosphoglycerate mutase is an enzyme involved in the glycolytic pathway, which is used by organisms to produce energy from glucose. It catalyzes the conversion of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA), which is an important step in the production of ATP.
The reaction catalyzed by phosphoglycerate mutase is reversible, meaning that it can also catalyze the conversion of 2-PGA to 3-PGA. This process is important in certain metabolic pathways, such as the one used by plants during the process of photorespiration.
Phosphoglycerate mutase exists in two different isoforms, which are designated as PGAM1 and PGAM2. PGAM1 is found in most tissues, while PGAM2 is primarily expressed in skeletal muscle. These isoforms differ in their structure and activity, and may have different roles in the regulation of glycolysis.
Overall, phosphoglycerate mutase plays an important role in the glycolytic pathway and in other metabolic processes. Its activity and regulation are therefore important considerations in understanding cellular metabolism and energy production.
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