phosphoglycerate kinase
phosphorylates 1,3-bisphosphoglycerate to 3-phosphoglycerateProduces ATP (payoff reaction)
Phosphoglycerate kinase (PGK) is an enzyme that plays an important role in the glycolytic pathway – a series of chemical reactions that occur in the cytoplasm of cells to generate energy from glucose. Specifically, PGK catalyzes the transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate.
The PGK enzyme is found in most organisms, ranging from bacteria to humans, and is highly conserved, meaning that its structure and function are very similar across different species. PGK deficiency is a rare genetic disorder that affects the energy production in cells and can lead to muscle weakness, developmental delays, and other health complications.
In terms of its structure, PGK is a homodimeric enzyme, meaning that it consists of two identical subunits that are joined together. Each subunit contains a catalytic domain, which is responsible for carrying out the chemical reactions, and a nucleotide-binding domain, which binds to the substrates and cofactors needed for the reaction to take place.
Overall, phosphoglycerate kinase is an important enzyme in the glycolytic pathway that helps generate ATP, the main source of energy for many cellular processes.
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