Hexokinase
Phosphorylates Glc to Glc6PThe enzymes that catalyzes the phosphorylation of glucose to form glucose-6-phosphate in the first step of glycolysis. This is one of the ain regulatory steps of this pathway. Hexokinase is feedback-inhibited by glucose-6-P.
Hexokinase is an enzyme that plays a crucial role in cellular metabolism. Specifically, it is responsible for catalyzing the first step in sugar metabolism, converting glucose to glucose-6-phosphate. This conversion is a critical step in the breakdown of glucose for energy production.
Hexokinase is found in many tissues of the body, including the liver, pancreas, and muscle tissue. There are multiple isoenzymes of hexokinase, each with varying kinetic properties and regulatory mechanisms. For example, hexokinase IV (also known as glucokinase) is unique to the liver and pancreas and has a higher Km for glucose compared to other hexokinase isoenzymes.
When glucose levels are high, hexokinase activity is increased to facilitate glucose utilization. Conversely, when glucose levels are low, hexokinase activity is decreased to conserve glucose for critical metabolic processes.
Overall, hexokinase is a critical enzyme in cellular metabolism that helps to regulate glucose utilization throughout the body.
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