Glyceraldehyde-3-phosphate dehydrogenase
Oxidation of Glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerateReduction of NAD+ to NADHRequires phosphate (Pi)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an important enzyme that plays a crucial role in cellular metabolism. It is an enzyme that facilitates the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate in the glycolytic pathway.
The glycolytic pathway is an essential process in most living organisms, including humans, as it helps to convert glucose into usable energy in the form of ATP. GAPDH is one of the key enzymes involved in this process and is responsible for catalyzing the step that converts glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate, which can then be used to generate ATP.
In addition to its role in glycolysis, GAPDH is also involved in various other cellular processes, including the regulation of cellular signaling pathways, apoptosis, and gene transcription. Interestingly, GAPDH has been found to be associated with a number of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, it has gained a lot of attention as a potential therapeutic target for the treatment of several diseases.
Overall, GAPDH plays a critical role in cellular metabolism and physiology and is an important enzyme in various biological processes.
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