Exploring a Missense Mutation in DNA Sequence 3: Substitution of Valine (Val) with Cysteine (Cys)

DNA sequence (normal) – TAC GTA GTC ACC TAA TGG ATC Amino acid sequence – met his gln trp ile thr stop sequence 3 TAC GTA TGT CAC CTA ATG GAT C… Amino acid sequence – met his thr val asp tyr leu… what type of mutation is sequence 3 and why?

Based on the given information, the original DNA sequence is TAC GTA GTC ACC TAA TGG ATC

Based on the given information, the original DNA sequence is TAC GTA GTC ACC TAA TGG ATC. The corresponding amino acid sequence is Met (start codon), His, Gln, Trp, Ile, Thr, and Stop codon.

The mutated sequence 3 is TAC GTA TGT CAC CTA ATG GAT C. The corresponding amino acid sequence is Met (start codon), His, Thr, Val, Asp, Tyr, and Leu.

To determine the type of mutation that occurred in sequence 3, we compare it to the normal sequence. In this case, a single nucleotide change has occurred, specifically at position 7 of the DNA sequence. The original nucleotide “G” has been mutated to “T” in sequence 3.

This mutation is a missense mutation. A missense mutation refers to a change in a single nucleotide that results in the alteration of a single amino acid in the resulting protein. In this case, the mutation at position 7 of the DNA sequence changed the codon from GTC (which codes for the amino acid “Val”) to TGT (which codes for the amino acid “Cys”). Therefore, the substitution of Valine (Val) with Cysteine (Cys) occurred in the resulting protein.

It’s important to note that the impact of a missense mutation on protein function depends on the context and the role of the affected amino acid within the protein’s structure and function. Valine and Cysteine have different chemical properties, so this mutation could potentially affect the protein’s structure, function, or both. Further analysis and experimentation would be required to determine the specific implications of this mutation.

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