Fatty acid synthesis begins with a transfer of the acetyl group from the acetyl CoA to fatty acid synthase. ___-carbon groups, supplied by ___, are added to the growing acyl chain in a series of steps involving condensation, ___, and dehydration reactions.
Twomalonyl CoAreduction
Fatty acid synthesis begins with a transfer of the acetyl group from the acetyl CoA to fatty acid synthase. Malonyl-CoA, a three-carbon molecule, is supplied by biotin carboxylase and added to the growing acyl chain in a series of steps involving condensation, reduction, and dehydration reactions. These reactions occur in the cytosol of the cell and are catalyzed by a single multi-enzyme complex known as fatty acid synthase. This complex incorporates two-carbon units from malonyl-CoA onto the growing fatty acid chain until the desired chain length is achieved. The process can be repeated to produce longer chains of fatty acids.
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