Exploring the Role of Negatively Charged Amino Acids: Aspartic Acid and Glutamic Acid

Which amino acids are negatively charged?

Asp, Glu

There are two amino acids that are negatively charged at physiological pH. These are aspartic acid (Asp or D) and glutamic acid (Glu or E). At pH 7.4, the carboxyl (COOH) group of these amino acids will be dissociated to yield a negatively charged carboxylate group (COO-), giving these amino acids a net negative charge.

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