Fumarase
Hydration of trans-fumarate to L-malateProduct is stereospecific
Fumarase is an enzyme that catalyzes the reversible conversion of fumarate to L-malate in the tricarboxylic acid (TCA) cycle. This enzyme is found in both prokaryotic and eukaryotic organisms and plays an essential role in cellular metabolism.
In the TCA cycle, fumarase catalyzes the conversion of fumarate, a four-carbon compound, to L-malate, a five-carbon compound. This reaction also produces a high-energy bond in the form of a molecule of ATP. The ATP produced in this reaction can be used by the cell for energy or stored for later use.
Fumarase is important for the proper functioning of the TCA cycle, which is responsible for the generation of energy in the form of ATP. Dysfunction of this enzyme can lead to a number of metabolic disorders. For example, mutations in the fumarase gene are associated with hereditary leiomyomatosis and renal cell carcinoma, a rare cancer syndrome.
In summary, fumarase is a key enzyme in the TCA cycle that plays an essential role in cellular metabolism. Dysfunction of this enzyme can lead to metabolic disorders and cancer.
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