inhibin
decreases FSH synthesis
Inhibin is a protein hormone that is primarily secreted by the gonads (testes in males and ovaries in females) and plays an important role in the regulation of the reproductive system. Inhibin inhibits the secretion of follicle-stimulating hormone (FSH) from the pituitary gland, thereby regulating the menstrual cycle in females and spermatogenesis in males.
In females, inhibin is primarily secreted by the granulosa cells of developing ovarian follicles. As the follicles mature, they produce increasing amounts of inhibin, which acts as a negative feedback signal to the pituitary gland to reduce the secretion of FSH. This helps to prevent the development of too many follicles at once, which could lead to multiple pregnancies.
In males, inhibin is produced by the Sertoli cells within the seminiferous tubules of the testes. It acts as an important regulator of spermatogenesis by inhibiting the release of FSH from the pituitary gland. This helps to maintain a balance between the production of sperm and the release of sex hormones in the male reproductive system.
Imbalances in inhibin levels can have significant effects on the reproductive system. For example, decreased levels of inhibin in females can cause an increase in FSH secretion, leading to infertility and irregular menstrual cycles. In males, decreased inhibin levels can result in impaired spermatogenesis and reduced fertility.
Overall, inhibin plays a crucial role in maintaining the balance and function of the reproductive system in both males and females.
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