How Testosterone Shapes Sexual Development: The Critical Role of the Wolffian System in Male Reproductive Tissue Formation

The absence of which major hormone is a determinant of sexualdifferentiation (wolffian system) in utero?a. Estrogen c. Growth hormoneb. Progesterone d. Testosterone

DIn the absence of testosterone, a loss of the wolffian system occurs and the two gonadsdevelop into ovaries at 6 to 8 weeks’ gestation. Between 6 and 7 weeks’ gestation, themale embryo differentiates under the influence of TDF. The presence of estrogen is adeterminating factor.

The absence of Testosterone is a determinant of sexual differentiation (wolffian system) in utero. Testosterone is the primary male sex hormone that plays a critical role in the development of male reproductive tissues, including the Wolffian duct system, which gives rise to the vas deferens, epididymis, and seminal vesicles. In the absence of testosterone, the Wolffian ducts regress, and the Müllerian duct system develops, resulting in the development of female reproductive organs.

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