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  • Mohamed Abbas
  • July 4, 2023
  • Biotechnology

Optimizing Oligonucleotide-Based Therapies: Addressing Stability and Bioavailability Challenges in Medicine

Mechanism of Action, Medicinal Chemistry of Oligonucleotides (Metabolism, Affinity, Synthesis), Toxicology, -BIGGEST PROBLEM – Less Stable in body, low bioavailability Oligonucleotides are short sequences of nucleotides (building...
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  • Mohamed Abbas
  • July 4, 2023
  • Biotechnology

Blocking Activation Site of Translation and Degradation by RNAse: Mechanisms to Inhibit Protein Synthesis in Science

1. Blocking activation site of translation.2. Degraded by an enzyme RNAse One way to block the activation site is by using molecules called antisense oligonucleotides 1. Blocking...
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  • Mohamed Abbas
  • July 4, 2023
  • Biotechnology

Advancements in Medication: Vitravene, KYNAMRO, Custirsen, ISIS GCGR, and Alicaforsen

Vitravene – Fomivirsen (marketed)KYNAMRO (approved)Custirsen (cancer drug, Phase III)ISIS GCGR (Phase II)Alicaforsen (approved) Vitravene, also known as Fomivirsen, is a medication that was previously marketed for the...
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  • Mohamed Abbas
  • July 4, 2023
  • Life Science

Achieving and Sustaining Balance: Key Aspects of Balancing Human and Living Organisms

balancing human or any living organisms Balancing human or any living organisms refers to maintaining a state of equilibrium in various aspects of their existence, including physical...
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  • Mohamed Abbas
  • July 4, 2023
  • Life Science

Unlocking the Secrets of Metabolism: Exploring the Chemical Processes within Living Cells

the chemical process occurring within a living cell or organism that are necessary for the maintenance of life The chemical processes occurring within a living cell or...
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  • Mohamed Abbas
  • July 4, 2023
  • Life Science

Unraveling the Genetics of Heredity: Understanding the Transmission of Traits from Parents to Offspring

Passing of traits from parents to offspring The passing of traits from parents to offspring is a fundamental concept in genetics and is known as heredity The...
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  • Mohamed Abbas
  • July 4, 2023
  • Life Science

The Golgi Apparatus: Function, Structure, and Protein Packaging in Eukaryotic Cells

packages proteins from the ER and materials and sends them to other parts of the cell The organelle that is responsible for packaging proteins from the endoplasmic...
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  • Mohamed Abbas
  • July 4, 2023
  • Life Science

The Versatile Functions of the Smooth Endoplasmic Reticulum: A Closer Look at Lipid Synthesis, Detoxification, and Calcium Regulation

ER that has no ribosomes, makes lipids The endoplasmic reticulum (ER) is a membrane-bound organelle found in eukaryotic cells responsible for various cellular functions The endoplasmic reticulum...
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