The Role of IgE Antibodies in Allergic Reactions and Immune Response Sensitization

Immunoglobulins that attach to and sensitize mast cells and basophils are A) IgA.B) IgD.C) IgE.D) IgG.E) IgM.

The immunoglobulins that attach to and sensitize mast cells and basophils are IgE (Option C)

The immunoglobulins that attach to and sensitize mast cells and basophils are IgE (Option C). IgE stands for immunoglobulin E, and it is one of the five major classes of antibodies produced by the immune system.

When an individual is exposed to an allergen (e.g., pollen, pet dander, or certain foods), their immune system can produce an excessive amount of IgE antibodies. These IgE antibodies bind to specific receptors on the surface of mast cells and basophils, which are types of immune cells involved in allergic reactions.

The binding of IgE to mast cells and basophils sensitizes them, meaning that they become primed and ready for a subsequent encounter with the same allergen. When the allergen re-enters the body and binds to the IgE antibodies on sensitized mast cells or basophils, it triggers the release of various chemicals, such as histamine. This release of chemicals leads to the symptoms associated with allergies, such as itching, sneezing, wheezing, or hives.

It is important to note that while IgE antibodies play a crucial role in allergic reactions, they also have normal physiological functions in the immune system, such as defending against certain parasites. However, when the IgE-mediated immune response becomes dysregulated and overly reactive to harmless substances, it leads to allergic conditions.

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