Understanding Watson-Crick Base Pairing: How to Convert an mRNA Sequence into DNA

mRNA Sequence provided – Convert it into DNA

To convert an mRNA sequence into a DNA sequence, you need to understand the basic principles of Watson-Crick base pairing

To convert an mRNA sequence into a DNA sequence, you need to understand the basic principles of Watson-Crick base pairing. In DNA, adenine (A) always pairs with thymine (T), and cytosine (C) always pairs with guanine (G). However, in mRNA, thymine is replaced with uracil (U). So, when converting an mRNA sequence into DNA, you need to substitute U with T.

Here is an example of how to convert an mRNA sequence into DNA:

Let’s consider the mRNA sequence: 5′-AUGCCUAUCAUGGAUGCUA-3′

1. Start by writing down the RNA sequence:
5′-AUGCCUAUCAUGGAUGCUA-3′

2. Replace each occurrence of U with T:
5′-AUGCCUAUCAUGGAUGCUA-3′
↓
5′-AUGCCUAUCAUGGAUGCUA-3′

3. Reverse the resulting DNA sequence to reflect the complementary nature of DNA strands:
5′-AUGCCUAUCAUGGAUGCUA-3′
↓
3′-TACGGATACTACCATAACGA-5′

So, the DNA sequence corresponding to the given mRNA sequence is 3′-TACGGATACTACCATAACGA-5′.

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