Hematopoietic Stem Cells: Versatile Differentiation Potential and Key Characteristics Explained

Which of the following is not characteristic of pluripotent hematopoietic stem cells?A. Possess self-renewal abilityB. Produce progenitor cells committed to a single cell lineageC. Express the stem cell marker CD 13 D. Are morphologically unrecognizable

The correct answer is B

The correct answer is B. Produce progenitor cells committed to a single cell lineage.

Pluripotent hematopoietic stem cells are a type of stem cell found in the bone marrow and umbilical cord blood. They are capable of differentiating into all types of blood cells. Let’s examine each answer choice in detail to understand why B is not characteristic of pluripotent hematopoietic stem cells.

A. Possess self-renewal ability: Pluripotent hematopoietic stem cells have the ability to self-renew, meaning they can divide and produce more stem cells. This helps maintain a constant pool of stem cells in the body.

B. Produce progenitor cells committed to a single cell lineage: This statement is not characteristic of pluripotent hematopoietic stem cells. Unlike progenitor cells, which are more specialized and committed to developing into a specific lineage, pluripotent hematopoietic stem cells are not committed to a single cell lineage. Instead, they retain the ability to differentiate into various types of blood cells, including red blood cells, white blood cells, and platelets.

C. Express the stem cell marker CD 13: Stem cells, including pluripotent hematopoietic stem cells, often express specific cell surface markers that help identify and distinguish them from other cell types. CD13 is indeed a stem cell marker. However, the expression of CD13 does not determine whether a cell is pluripotent.

D. Are morphologically unrecognizable: Pluripotent hematopoietic stem cells do not have a distinct morphological appearance. This means they cannot be easily identified based on visual characteristics alone. Instead, specific markers and functional assays are used to identify and purify these cells.

In summary, pluripotent hematopoietic stem cells do not produce progenitor cells committed to a single cell lineage (answer choice B). Their ability to differentiate into multiple types of blood cells and their lack of a distinct morphological appearance are key characteristics of these stem cells.

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