Which azole drug causes endocrine ADRs (gynecomastia, decreased libido, oligospermia)?
The azole drug that is predominantly associated with endocrine-related adverse drug reactions (ADRs) such as gynecomastia, decreased libido, and oligospermia is called ketoconazole
The azole drug that is predominantly associated with endocrine-related adverse drug reactions (ADRs) such as gynecomastia, decreased libido, and oligospermia is called ketoconazole. This antifungal medication belongs to the azole class of drugs and is commonly used to treat fungal infections.
Ketoconazole works by inhibiting the synthesis of ergosterol, which is a key component of the fungal cell membrane. However, it can also inhibit the synthesis of several hormones in the human body, including the synthesis of testosterone and adrenal corticosteroids.
The inhibition of testosterone synthesis by ketoconazole can result in a decrease in libido, gynecomastia (enlargement of male breast tissue), and oligospermia (reduced sperm count). These ADRs are considered endocrine-related because they involve disruptions in the normal hormonal balance of the body.
It is worth noting that ketoconazole’s inhibitory effects on hormone synthesis are dose-dependent. Higher doses of the drug are more likely to cause endocrine-related ADRs. However, it is also important to mention that ketoconazole is now less frequently prescribed due to its potential for serious liver toxicity.
If you are prescribed ketoconazole or any other medication, it is crucial to discuss any concerns or potential side effects with your healthcare provider, as they can provide personalized advice and alternative treatment options if necessary.
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