Understanding the Role of Phosphorylation in Energy Balance: AMP-activated Protein Kinase and Acetyl CoA Carboxylase Interaction

Phosphorylation of acetyl CoA carboxylase (the enzyme that converts acetyl CoA to malonyl CoA) by AMP-activated protein kinase has what effect?a. Inactivates the enzymeb. Activates the enzymec. Partially activates the enzyme d. Causes the cell to explodee. Prevents the binding of citrate

a. Inactivates the enzyme

Phosphorylation of acetyl CoA carboxylase by AMP-activated protein kinase activates the enzyme. The activation of acetyl CoA carboxylase leads to the conversion of acetyl CoA into malonyl CoA. This process is essential for fatty acid synthesis and the regulation of cellular energy balance. The AMP-activated protein kinase (AMPK) pathway is a key regulator of energy homeostasis, and AMPK activation promotes energy-generating pathways, such as fatty acid oxidation, while inhibiting energy-consuming pathways, such as fatty acid synthesis. Therefore, phosphorylation of acetyl CoA carboxylase plays an important role in maintaining cellular energy balance and preventing the formation of excess fatty acids.

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