Understanding β-Oxidation: The Importance of Oxidation to Generate trans-Δ2-Enoyl CoA in Fatty Acid Breakdown

One of the steps in β-oxidation is the oxidation of L-3-Hydroxyacyl CoA to generate 3-Ketoacyl CoA. What is the next step?a. Oxidation to generate trans-Δ2-Enoyl CoAb. Thiolysis to generate Acetyl CoA and a shortened Acyl CoAc. Hydration to generate D-3-Hydroxybutyryl CoA d. Condensation to form Acetoacetyl CoAe. Isomerization to form trans-Δ3-Enoyl CoA

b. Thiolysis to generate Acetyl CoA and a shortened Acyl CoA

The next step in β-oxidation after the oxidation of L-3-Hydroxyacyl CoA to generate 3-Ketoacyl CoA is the oxidation to generate trans-Δ2-Enoyl CoA. The complete process of β-oxidation involves several steps where fatty acids are broken down into acetyl-CoA. The steps of β-oxidation are:

1. Activation: The fatty acids are activated with the help of Coenzyme A (CoA) to form acyl-CoA.

2. Oxidation: The first step of oxidation occurs where the FAD (Flavin adenine dinucleotide) accepts a hydrogen ion (H+) from the fatty acid chain giving rise to FADH2. This step produces trans-Δ2-Enoyl CoA.

3. Hydration: Water is added to the double bond formed in the previous step to give rise to L-3-Hydroxyacyl CoA.

4. Oxidation: In this step, NAD+ (nicotinamide adenine dinucleotide) accepts a hydrogen ion from the L-3-Hydroxyacyl CoA, which yields NADH and 3-Ketoacyl CoA.

5. Thiolysis: The cleavage of 3-Ketoacyl CoA occurs where the CoA molecule is added to the broken bond. This step yields Acetyl-CoA and a shortened Acyl-CoA, which starts the cycle again.

So, the next step after the oxidation of L-3-Hydroxyacyl CoA to generate 3-Ketoacyl CoA in β-oxidation is the oxidation to generate trans-Δ2-Enoyl CoA.

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