Fatty acid mobilization begins with hormonal signaling to adipocytes (fat cells). Once these cells receive this signal, what is the next step in fatty acid processing? a. Transport of fatty acids in blood stream to appropriate tissues.b. Hydrolysis of triacylglycerols by lipases.c. Transport of fatty acids into the mitochondria. d. Activation of fatty acids by the addition of CoA.e. β-oxidation.
b. Hydrolysis of triacylglycerols by lipases.
b. Hydrolysis of triacylglycerols by lipases.
Once adipocytes receive hormonal signaling, lipases are activated to cleave the ester bonds between fatty acids and glycerol, leading to the release of free fatty acids into the bloodstream. This process is known as lipolysis. The free fatty acids are then transported to the appropriate tissues, where they can be taken up by the cells and undergo β-oxidation. Before they can enter β-oxidation, however, the fatty acids must be activated by the addition of CoA. This step is known as activation and occurs in the cytosol.
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