True or False Protein functional annotation by sequence similarity requires an efficient sequence alignment tool such as BLAST and a high-quality database of known protein sequences.
T
True.
Protein functional annotation by sequence similarity involves comparing the sequence of a protein of interest with a large database of known protein sequences in order to infer its function. This comparison can only be accurate if an efficient sequence alignment tool, such as BLAST, is used in combination with a high-quality database of known protein sequences. The accuracy of the analysis will depend on the quality of the database and the significance threshold used for the sequence similarity search.
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