Exploring the Vital Role of Transferases in Cellular Processes and Disease States

Enzymes that catalyze the transfer of functional groups between molecules

Transferase

Enzymes that catalyze the transfer of functional groups between molecules are called Transferases. These enzymes facilitate the transfer of a functional group between two molecules, an acceptor molecule and a donor molecule. Transferases catalyze the transfer of numerous functional groups, including methyl, phosphate, acyl, and glycosyl groups, among others.

For example, the enzyme alanine transaminase (ALT) is a transferase that catalyzes the transfer of an amino group from alanine to alpha-ketoglutarate, which results in the formation of glutamate and pyruvate.

Another example is the enzyme hexokinase, which is a transferase that catalyzes the transfer of a phosphate group from ATP to glucose, producing glucose-6-phosphate.

Transferases are important in numerous cellular processes such as metabolism, signal transduction, and protein synthesis. The regulation of transferases activity plays a vital role in the maintenance of cellular homeostasis, and the dysregulation of transferases activity is associated with various disease states, including cancer and metabolic disorders.

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