HGPRT
transfers hypoxanthine or guanine to PRPP to form IMP or GMP respectivelysalvage pathway
HGPRT stands for hypoxanthine-guanine phosphoribosyltransferase. It is an enzyme that plays a crucial role in the recycling of purine nucleotides in the body, particularly in the salvage pathway of nucleotide biosynthesis.
Individuals with a deficiency of HGPRT enzyme activity cannot effectively salvage purine nucleotides, resulting in their accumulation and the formation of uric acid crystals in the joints, leading to a condition called gout. This is because HGPRT helps to convert hypoxanthine or guanine to their respective nucleotides, which can then be used in DNA and RNA synthesis. Without HGPRT, the accumulation of hypoxanthine and guanine leads to increased uric acid levels, thereby causing gout.
However, mutations in the HGPRT gene can also cause Lesch-Nyhan syndrome, which is a rare genetic disorder that affects the nervous system, causing intellectual disability, self-injurious behavior, gout, and muscle weakness, among other symptoms.
Therefore, the correct functioning of the HGPRT enzyme is essential for purine metabolism and overall bodily health.
More Answers:
Understanding Lesch-Nyhan Syndrome: Causes, Symptoms, and Treatment OptionsUnderstanding Hyperuricemia: Causes, Complications, and Treatment Options
The Role of Xanthine Oxidase (XO) Enzyme in Purine Nucleotide Metabolism and Treatment of Gout: A Comprehensive Overview.