Blood pH Regulation: The Vital Role of Carbonic Acid and Bicarbonate Ion Buffering System

The pH of blood is buffered by the conjugate acid-base pair of _______ acid and __________.

Carbonic acid and bicarbonate

The pH of blood is buffered by the conjugate acid-base pair of carbonic acid and bicarbonate ion. Carbonic acid (H2CO3) can donate a proton (H+) and become bicarbonate ion (HCO3-), acting as a weak acid. In the opposite direction, bicarbonate ion can accept a proton and form carbonic acid, acting as a weak base. This buffering system helps maintain the pH of blood between 7.35 and 7.45, which is critical for proper bodily functions.

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