last reaction of heme synthesis
ferrochelatase (enzyme) chelates ferrous iron into protoporphyrin IX to form heme. Occurs in mitochondria
The final step in the heme synthesis pathway is the insertion of an iron atom into protoporphyrin IX to form heme. This reaction is catalyzed by the enzyme ferrochelatase. The iron atom is sourced from either a circulating pool of free iron or from iron that has been stored in the cell as ferritin. The iron is inserted into the center of the protoporphyrin ring through a chelation process, which stabilizes the iron-protoporphyrin complex. Heme is an essential component of many proteins, including hemoglobin, myoglobin, and cytochromes, which are involved in oxygen transport, energy metabolism, and important cellular processes.
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