When the following receptors are engaged, what mechanism is initiated in a phagocyte?Mannose receptor:
Activates Lectin complement cascade, binds to particular carbohydrates NOT found on human cells.
When the Mannose receptor is engaged in a phagocyte, the mechanism that is initiated is the recognition of sugar residues on the surfaces of microorganisms by the receptor. The Mannose receptor is a type of lectin receptor that specifically binds to the sugar mannose, which is abundant on the surface of many microorganisms, including bacteria, fungi, viruses and parasites.
When the Mannose receptor recognizes mannose on a microorganism, it triggers a signal cascade inside the phagocyte that leads to the internalization of the microorganism through phagocytosis. This involves the formation of a phagosome, which is essentially a membrane-bound vesicle that contains the microorganism. The phagosome then fuses with a lysosome, a type of organelle that contains enzymes capable of breaking down the microorganism.
Overall, engagement of the Mannose receptor on a phagocyte leads to the recognition and uptake of microorganisms containing mannosylated molecules, which is an important mechanism for the clearance of pathogens from the body.
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