Drugs that are administered by skin patches tend to be _______ soluble molecules that are absorbed ________.
lipid; slowly
Drugs that are administered by skin patches tend to be lipophilic (fat-loving) or hydrophobic (water-repelling) molecules that are absorbed slowly and evenly through the skin. These drugs are usually in the form of a viscous liquid or a solid matrix that contains the drug in a dissolved or dispersed state. The patch is designed to allow the drug to slowly diffuse through the skin and into the bloodstream. Lipophilic or hydrophobic molecules tend to be absorbed more efficiently across the skin due to the highly lipophilic nature of the stratum corneum, which is the outermost layer of the skin. Additionally, the slow-release characteristics of the skin patch allow for a more sustained and controlled release of the drug than other administration routes, which can result in more stable blood levels of the drug and potentially reduce the risk of adverse effects.
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